NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks

Chromatin remodeling factors play an active role in the DNA damage response by shaping chromatin to facilitate the repair process. The spatiotemporal regulation of these factors is key to their function, yet poorly understood. We report that the structural nuclear protein NuMA accumulates at sites o...

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Hlavní autoři: Vidi, Pierre-Alexandre, Liu, Jing, Salles, Daniela, Jayaraman, Swaathi, Dorfman, George, Gray, Matthew, Abad, Patricia, Moghe, Prabhas V., Irudayaraj, Joseph M., Wiesmüller, Lisa, Lelièvre, Sophie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041463/
https://ncbi.nlm.nih.gov/pubmed/24753406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku296
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