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Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation
Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited to the exon by Tra2-β1. We report that in addition to the C-termi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041419/ https://ncbi.nlm.nih.gov/pubmed/24692659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku244 |
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