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Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy

Cell signaling is often mediated by the binding of multiple ligands to a multi-subunit receptor. The probabilistic nature and slow rate of binding of diffusible ligands at low concentrations can impede attempts to determine how ligand occupancy controls signaling in such protein complexes. We descri...

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Hlavní autoři: Reiner, Andreas, Isacoff, Ehud Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041372/
https://ncbi.nlm.nih.gov/pubmed/24561661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1458
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