Resistance to simian immunodeficiency virus low dose rectal challenge is associated with higher constitutive TRIM5α expression in PBMC

BACKGROUND: At least six host-encoded restriction factors (RFs), APOBEC3G, TRIM5α, tetherin, SAMHD1, schlafen 11, and Mx2 have now been shown to inhibit HIV and/or SIV replication in vitro. To determine their role in vivo in the resistance of macaques to mucosally-acquired SIV, we quantified both pr...

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Autors principals: Aamer, Hadega A, Rajakumar, Premeela, Nyaundi, Julia, Murphey-Corb, Michael
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041354/
https://ncbi.nlm.nih.gov/pubmed/24884551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-39
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