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Structural Insights into PDZ-mediated Interaction of NHERF2 and LPA(2), a Cellular Event Implicated in CFTR Channel Regulation
The formation of CFTR-NHERF2-LPA(2) macromolecular complex in airway epithelia regulates CFTR channel function and plays an important role in compartmentalized cAMP signaling. We previously have shown that disruption of the PDZ-mediated NHERF2-LPA(2) interaction abolishes the LPA inhibitory effect a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041278/ https://ncbi.nlm.nih.gov/pubmed/24613836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.02.128 |
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