Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Neutrophil plays an essential role in host defense against infection, but uncontrolled neutrophilic infiltration can cause inflammation and severe epithelial damage. We recently showed that CXCR2 formed a signaling complex with NHERF1 and PLC-2, and that the formation of this complex was required fo...

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Detalhes bibliográficos
Main Authors: Lu, Guorong, Wu, Yanning, Jiang, Yuanyuan, Wang, Shuo, Hou, Yuning, Guan, Xiaoqing, Brunzelle, Joseph, Sirinupong, Nualpun, Sheng, Shijie, Li, Chunying, Yang, Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788737/
https://ncbi.nlm.nih.gov/pubmed/24098448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076219
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