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Cyclosporine Preserves Mitochondrial Morphology After Myocardial Ischemia/Reperfusion Independent of Calcineurin Inhibition

BACKGROUND: Opening of the mitochondrial permeability transition pore (MPTP) has been shown to contribute to myocardial ischemia/reperfusion injury. We sought to demonstrate that the myocardial protective effect of inhibiting MPTP opening with cyclosporine A (CsA) results in stabilization of mitocho...

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Detalhes bibliográficos
Main Authors: Leshnower, Bradley G., Kanemoto, Shinya, Matsubara, Muneaki, Sakamoto, Hiroaki, Hinmon, Robin, Gorman, Joseph H., Gorman, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041111/
https://ncbi.nlm.nih.gov/pubmed/18805178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2008.06.033
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