Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymp...

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Detalhes bibliográficos
Main Authors: Gomes, A. Margarida, Soares, Maria V. D., Ribeiro, Patrícia, Caldas, Joana, Póvoa, Vanda, Martins, Leila R., Melão, Alice, Serra-Caetano, Ana, de Sousa, Aida B., Lacerda, João F., Barata, João T.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040910/
https://ncbi.nlm.nih.gov/pubmed/24561792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.096438
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