The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice

Transferrin receptor 2 (TFR2) is a transmembrane glycoprotein expressed in the liver and in the erythroid compartment, mutated in a form of hereditary hemochromatosis. Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator hepcidin, while erythroid TFR2 is a member of the...

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Main Authors: Nai, Antonella, Pellegrino, Rosa M., Rausa, Marco, Pagani, Alessia, Boero, Martina, Silvestri, Laura, Saglio, Giuseppe, Roetto, Antonella, Camaschella, Clara
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040905/
https://ncbi.nlm.nih.gov/pubmed/24658816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.103143
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