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Irregular telomeres impair meiotic synapsis and recombination in mice

Telomere shortening can lead to chromosome instability, replicative senescence, and apoptosis in both somatic and male germ cells. To study roles for mammalian telomeres in homologous pairing and recombination, we characterized effects of telomere shortening on spermatogenesis and oogenesis in late-...

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Detalhes bibliográficos
Main Authors: Liu, Lin, Franco, Sonia, Spyropoulos, Barbara, Moens, Peter B., Blasco, Maria A., Keefe, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC404073/
https://ncbi.nlm.nih.gov/pubmed/15084742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400755101
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