GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis

Abnormal Sonic Hedgehog signalling leads to increased transcriptional activation of its downstream effector, glioma 2 (GLI2), which is implicated in the pathogenesis of a variety of human cancers. However, the mechanisms underlying the tumorigenic role of GLI2 remain elusive. We demonstrate that ove...

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Bibliografiske detaljer
Main Authors: Pantazi, E, Gemenetzidis, E, Trigiante, G, Warnes, G, Shan, L, Mao, X, Ikram, M, Teh, M-T, Lu, Y-J, Philpott, M P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040660/
https://ncbi.nlm.nih.gov/pubmed/24481442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.535
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