HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

Overexpression of the human epidermal growth factor receptor-2 (HER2) in breast cancer strongly correlates with aggressive tumors and poor prognosis. Recently, a positive correlation between HER2 and MIF (macrophage migration inhibitory factor, a tumor-promoting protein and heat-shock protein 90 (HS...

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Главные авторы: Schulz, R, Streller, F, Scheel, A H, Rüschoff, J, Reinert, M-C, Dobbelstein, M, Marchenko, N D, Moll, U M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040658/
https://ncbi.nlm.nih.gov/pubmed/24384723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.508
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