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Stochastic model of protein–protein interaction: Why signaling proteins need to be colocalized

Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the...

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Detalhes bibliográficos
Main Authors: Batada, Nizar N., Shepp, Larry A., Siegmund, David O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC404064/
https://ncbi.nlm.nih.gov/pubmed/15096590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401314101
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