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Stochastic model of protein–protein interaction: Why signaling proteins need to be colocalized

Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the...

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Autors principals: Batada, Nizar N., Shepp, Larry A., Siegmund, David O.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC404064/
https://ncbi.nlm.nih.gov/pubmed/15096590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401314101
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