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Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation

A major goal for immunotherapy is to tolerize the immune cells that coordinate tissue damage in autoimmune and alloantigen responses. CD4 T cells play a central role in many of these conditions and improved antigen-specific regulation or removal of these cells could revolutionize current treatments....

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Autores principales: David, Alexandria, Crawford, Frances, Garside, Paul, Kappler, John W., Marrack, Philippa, MacLeod, Megan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040609/
https://ncbi.nlm.nih.gov/pubmed/24821788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406218111
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