Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation. The transition from steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Under normal conditions, lipoproteins that are endoc...

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Bibliographische Detailangaben
Hauptverfasser: Bieghs, Veerle, Walenbergh, Sofie M. A., Hendrikx, Tim, van Gorp, Patrick J., Verheyen, Fons, Damink, Steven W. Olde, Masclee, Ad A., Koek, Ger H., Hofker, Marten H., Binder, Christoph J., Shiri-Sverdlov, Ronit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040540/
https://ncbi.nlm.nih.gov/pubmed/23617943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12170
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