Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

BACKGROUND AND PURPOSE: Activated Protein C (APC) stimulates multiple cytoprotective pathways via the protease activated receptor-1 (PAR-1) and promotes anticoagulation. 3K3A-APC was designed for preserved activity at PAR-1 with reduced anticoagulation. This Phase 1 trial characterized pharmacokinet...

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Autori principali: Lyden, Patrick, Levy, Howard, Weymer, Sara, Pryor, Kent, Kramer, William, Griffin, John H., Davis, Thomas P., Zlokovic, Berislav
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040367/
https://ncbi.nlm.nih.gov/pubmed/24372304
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