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Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance

Gene signatures have failed to predict responses to breast cancer therapy in patients to date. In this study, we used bioinformatic methods to explore the hypothesis that the existence of multiple drug resistance mechanisms in different patients may limit the power of gene signatures to predict resp...

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Bibliografski detalji
Glavni autori: Ng, Charlotte K. Y., Weigelt, Britta, A’Hern, Roger, Bidard, Francois-Clement, Lemetre, Christophe, Swanton, Charles, Shen, Ronglai, Reis-Filho, Jorge S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040235/
https://ncbi.nlm.nih.gov/pubmed/24706696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3375
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