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Immune escape from NY-ESO-1-specific T cell therapy via loss of heterozygosity in the MHC
Adoptive immunotherapy of tumors with T cells specific for the cancer-testis antigen NY-ESO-1 has shown great promise in preclinical models and in early stage clinical trials. Tumor persistence or recurrence after NY-ESO-1-specific therapy occurs, however, and the mechanisms of recurrence remain poo...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040020/ https://ncbi.nlm.nih.gov/pubmed/24451117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.87 |
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