Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

Farnesoid X receptor (FXR, Nr1h4) and small heterodimer partner (SHP, Nr0b2) are nuclear receptors that are critical to liver homeostasis. Induction of SHP serves as a major mechanism of FXR in suppressing gene expression. Both FXR(−/−) and SHP(−/−) mice develop spontaneous hepatocellular carcinoma...

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Main Authors: Li, Guodong, Kong, Bo, Zhu, Yan, Zhan, Le, Williams, Jessica A., Tawfik, Ossama, Kassel, Karen M., Luyendyk, James P., Wang, Li, Guo, Grace L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039201/
https://ncbi.nlm.nih.gov/pubmed/23811326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.06.016
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