Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein

Influenza A virus RNA synthesis is catalyzed by the viral polymerase comprised of the PA, PB1 and PB2 proteins. We show that the host DDX21 RNA helicase restricts influenza A virus by binding PB1 and inhibiting polymerase assembly, resulting in reduced viral RNA and protein synthesis. Later during i...

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Bibliografiske detaljer
Main Authors: Chen, Guifang, Liu, Chien-Hung, Zhou, Ligang, Krug, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039189/
https://ncbi.nlm.nih.gov/pubmed/24721576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.03.002
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