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Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein
Influenza A virus RNA synthesis is catalyzed by the viral polymerase comprised of the PA, PB1 and PB2 proteins. We show that the host DDX21 RNA helicase restricts influenza A virus by binding PB1 and inhibiting polymerase assembly, resulting in reduced viral RNA and protein synthesis. Later during i...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4039189/ https://ncbi.nlm.nih.gov/pubmed/24721576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.03.002 |
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