PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

Control of BRAF(V600E) metastatic melanoma by BRAF inhibitor (BRAF-I) is limited by intrinsic and acquired resistance. Growth factor receptor up-regulation is among the mechanisms underlying BRAF-I resistance of melanoma cells. Here we demonstrate for the first time that PDGFRα up-regulation causes...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sabbatino, Francesco, Wang, Yangyang, Wang, Xinhui, Flaherty, Keith T., Yu, Ling, Pepin, David, Scognamiglio, Giosue', Pepe, Stefano, Kirkwood, John M., Cooper, Zachary A., Frederick, Dennie T., Wargo, Jennifer A., Ferrone, Soldano, Ferrone, Cristina R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039118/
https://ncbi.nlm.nih.gov/pubmed/24732172
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados