Antagonism of Tumoral Prolactin Receptor Promotes Autophagy Related Cell Death

Summary Therapeutic upregulation of macroautophagy in cancer cells provides an alternative mechanism for cell death. Prolactin (PRL) and its receptor (PRLR) are considered attractive therapeutic targets because of their roles as growth factors in tumor growth and progression. We utilized a novel ant...

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Hlavní autoři: Wen, Yunfei, Zand, Behrouz, Ozpolat, Bulent, Szczepanski, Miroslaw J., Lu, Chunhua, Yuca, Erkan, Carroll, Amy R., Alpay, Neslihan, Bartholomeusz, Chandra, Tekedereli, Ibrahim, Kang, Yu, Rupaimoole, Rajesha, Pecot, Chad V., Dalton, Heather J., Hernandez, Anadulce, Lokshin, Anna, Lutgendorf, Susan K., Liu, Jinsong, Hittelman, Walter N., Chen, Wen Y., Lopez-Berestein, Gabriel, Szajnik, Marta, Ueno, Naoto T., Coleman, Robert L., Sood, Anil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038960/
https://ncbi.nlm.nih.gov/pubmed/24703838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.009
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