Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

BACKGROUND: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish t...

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Autori principali: Zhou, Kaixin, Donnelly, Louise, Yang, Jian, Li, Miaoxin, Deshmukh, Harshal, Van Zuydam, Natalie, Ahlqvist, Emma, Spencer, Chris C, Groop, Leif, Morris, Andrew D, Colhoun, Helen M, Sham, Pak C, McCarthy, Mark I, Palmer, Colin N A, Pearson, Ewan R
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Lancet, Diabetes & Endocrinology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038749/
https://ncbi.nlm.nih.gov/pubmed/24731673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-8587(14)70050-6
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