Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

PKA phosphorylates multiple molecules involved in calcium (Ca(2+)) handling in cardiac myocytes and is considered to be the predominant regulator of β-adrenergic receptor–mediated enhancement of cardiac contractility; however, recent identification of exchange protein activated by cAMP (EPAC), which...

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Autores principales: Okumura, Satoshi, Fujita, Takayuki, Cai, Wenqian, Jin, Meihua, Namekata, Iyuki, Mototani, Yasumasa, Jin, Huiling, Ohnuki, Yoshiki, Tsuneoka, Yayoi, Kurotani, Reiko, Suita, Kenji, Kawakami, Yuko, Hamaguchi, Shogo, Abe, Takaya, Kiyonari, Hiroshi, Tsunematsu, Takashi, Bai, Yunzhe, Suzuki, Sayaka, Hidaka, Yuko, Umemura, Masanari, Ichikawa, Yasuhiro, Yokoyama, Utako, Sato, Motohiko, Ishikawa, Fumio, Izumi-Nakaseko, Hiroko, Adachi-Akahane, Satomi, Tanaka, Hikaru, Ishikawa, Yoshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038559/
https://ncbi.nlm.nih.gov/pubmed/24892712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64784
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