Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47(phox)-Mutant Mice

BACKGROUND: Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colit...

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Autores principales: Rodrigues-Sousa, Tiago, Ladeirinha, Ana Filipa, Santiago, Ana Raquel, Carvalheiro, Helena, Raposo, Bruno, Alarcão, Ana, Cabrita, António, Holmdahl, Rikard, Carvalho, Lina, Souto-Carneiro, M. Margarida
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038546/
https://ncbi.nlm.nih.gov/pubmed/24873968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097532
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