Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

We show here that human embryonic stem (ES) and induced pluripotent stem cell–derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell...

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מידע ביבליוגרפי
Main Authors: He, Qian, Wang, Guanghu, Wakade, Sushama, Dasgupta, Somsankar, Dinkins, Michael, Kong, Ji Na, Spassieva, Stefka D., Bieberich, Erhard
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Cell Biology 2014
נושאים:
Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038499/
https://ncbi.nlm.nih.gov/pubmed/24694597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-12-0730
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