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Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide
We show here that human embryonic stem (ES) and induced pluripotent stem cell–derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038499/ https://ncbi.nlm.nih.gov/pubmed/24694597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-12-0730 |
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