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Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

We show here that human embryonic stem (ES) and induced pluripotent stem cell–derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell...

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Bibliografske podrobnosti
Main Authors: He, Qian, Wang, Guanghu, Wakade, Sushama, Dasgupta, Somsankar, Dinkins, Michael, Kong, Ji Na, Spassieva, Stefka D., Bieberich, Erhard
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038499/
https://ncbi.nlm.nih.gov/pubmed/24694597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-12-0730
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