Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD d...

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Main Authors: Howarth, Deanna L., Lindtner, Claudia, Vacaru, Ana M., Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038464/
https://ncbi.nlm.nih.gov/pubmed/24874946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004335
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