Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes

BACKGROUND: Many alcoholic patients have serum protein deficiency that contributes to their systemic problems. The unfolded protein response (UPR) is induced in response to disequilibrium in the protein folding capability of the endoplasmic reticulum (ER) and is implicated in hepatocyte lipid accumu...

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Autori principali: Howarth, Deanna L., Vacaru, Ana M., Tsedensodnom, Orkhontuya, Mormone, Elisabetta, Nieto, Natalia, Costantini, Lindsey M., Snapp, Erik L., Sadler, Kirsten C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204333/
https://ncbi.nlm.nih.gov/pubmed/21790674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01602.x
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