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Applying a Multitarget Rational Drug Design Strategy: a First Set of Modulators with Potent and Balanced Activity toward Dopamine D3 Receptor and Fatty Acid Amide Hydrolase
Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. Concurrently modulating these targets, our compounds hold a great potential toward exerting a disea...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038168/ https://ncbi.nlm.nih.gov/pubmed/24691497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc00967c |
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