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λ-prophage induction modeled as a cooperative failure mode of lytic repression
We analyze a system-level model for lytic repression of λ-phage in E. coli using reliability theory, showing that the repressor circuit comprises 4 redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038166/ https://ncbi.nlm.nih.gov/pubmed/19905052 |
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