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Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model: ATP-gated P2X(3) Channels in EC are Downregulated in Ulcerative Colitis

BACKGROUND: Alterations in 5-hydroxytryptamine (HT) signaling in inflamed gut may contribute to pathogenesis of inflammatory bowel diseases. Adenosine 5′-triphosphate (ATP) regulates mucosal-mechanosensory reflexes and ATP receptors are sensitive to mucosal inflammation. Yet, it remains unknown whet...

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Hlavní autoři:	Liñán-Rico, Andrómeda, Wunderlich, Jacqueline E., Grants, Iveta S., Frankel, Wendy L., Xue, Jianjing, Williams, Kent C., Harzman, Alan E., Enneking, Joshua T., Cooke, Helen J., Christofi, Fievos L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2013
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4037929/ https://ncbi.nlm.nih.gov/pubmed/23917247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0b013e31829ecf4d
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Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model: ATP-gated P2X(3) Channels in EC are Downregulated in Ulcerative Colitis

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