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Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
BACKGROUND: Sorafenib (Sb) is a multiple kinase inhibitor targeting both tumour cell proliferation and angiogenesis that may further act as a potent radiosensitizer by arresting cells in the most radiosensitive cell cycle phase. This phase I open-label, noncontrolled dose escalation study was perfor...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4037825/ https://ncbi.nlm.nih.gov/pubmed/24786603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.209 |
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