A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas

PURPOSE: Despite recent advances in the management of high-grade and recurrent gliomas, survival remains poor. Antiangiogenic therapy has been shown to be efficacious in the treatment of high-grade gliomas both in preclinical models and in clinical trials. We sought to determine the safety and maxim...

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Detalhes bibliográficos
Main Authors: Den, Robert B., Kamrava, Mitchell, Sheng, Zhi, Werner-Wasik, Maria, Dougherty, Erin, Marinucchi, Michelle, Lawrence, Yaacov R., Hegarty, Sarah, Hyslop, Terry, Andrews, David W., Glass, Jon, Friedman, David P., Green, Michael R., Camphausen, Kevin, Dicker, Adam P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635494/
https://ncbi.nlm.nih.gov/pubmed/22687197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2012.04.017
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