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Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods

Here we address the problem of parameter estimation (inverse problem)of nonlinear dynamic biochemical pathways. This problem is stated as a nonlinear programming (NLP)problem subject to nonlinear differential-algebraic constraints. These problems are known to be frequently ill-conditioned and multim...

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Autors principals: Moles, Carmen G., Mendes, Pedro, Banga, Julio R.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC403766/
https://ncbi.nlm.nih.gov/pubmed/14559783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1262503
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