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Parameter Estimation in Biochemical Pathways: A Comparison of Global Optimization Methods
Here we address the problem of parameter estimation (inverse problem)of nonlinear dynamic biochemical pathways. This problem is stated as a nonlinear programming (NLP)problem subject to nonlinear differential-algebraic constraints. These problems are known to be frequently ill-conditioned and multim...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC403766/ https://ncbi.nlm.nih.gov/pubmed/14559783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1262503 |
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