MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart

BACKGROUND: Mechanical unloading of the failing human heart induces profound cardiac changes resulting in the reversal of a distorted structure and function. In this process, cardiomyocytes break down unneeded proteins and replace those with new ones. The specificity of protein degradation via the u...

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Hauptverfasser: Baskin, Kedryn K., Rodriguez, Meredith R., Kansara, Seema, Chen, Wenhao, Carranza, Sylvia, Frazier, O. Howard, Glass, David J., Taegtmeyer, Heinrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037330/
https://ncbi.nlm.nih.gov/pubmed/24650875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.03.006
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