Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice

Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insulin resistance and inflammation in mice....

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Main Authors: Lancha, Andoni, Rodríguez, Amaia, Catalán, Victoria, Becerril, Sara, Sáinz, Neira, Ramírez, Beatriz, Burrell, María A., Salvador, Javier, Frühbeck, Gema, Gómez-Ambrosi, Javier
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037189/
https://ncbi.nlm.nih.gov/pubmed/24871103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098398
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