Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice

Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insulin resistance and inflammation in mice....

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Main Authors: Lancha, Andoni, Rodríguez, Amaia, Catalán, Victoria, Becerril, Sara, Sáinz, Neira, Ramírez, Beatriz, Burrell, María A., Salvador, Javier, Frühbeck, Gema, Gómez-Ambrosi, Javier
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037189/
https://ncbi.nlm.nih.gov/pubmed/24871103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098398
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