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Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice
Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insulin resistance and inflammation in mice....
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Główni autorzy: | , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
Public Library of Science
2014
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4037189/ https://ncbi.nlm.nih.gov/pubmed/24871103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098398 |
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