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Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-Specific Gene Duplication
In mammals, the unique midkine (mdk) gene encodes a secreted heparin-binding growth factor with neurotrophic activity. Here, we show the presence of two functional mdk genes named mdka and mdkb in zebrafish and rainbow trout. Both midkine proteins are clearly different from the related pleiotrophin,...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC403662/ https://ncbi.nlm.nih.gov/pubmed/12743018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1097503 |
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