Development of a Membrane-anchored Chemerin Receptor Agonist as a Novel Modulator of Allergic Airway Inflammation and Neuropathic Pain

The chemerin receptor (CMKLR1) is a G protein-coupled receptor found on select immune, epithelial, and dorsal root ganglion/spinal cord neuronal cells. CMKLR1 is primarily coupled to the inhibitory G protein, Gα(i), and has been shown to modulate the resolution of inflammation and neuropathic pain....

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Hlavní autoři: Doyle, Jamie R., Krishnaji, Subrahmanian T., Zhu, Guangli, Xu, Zhen-Zhong, Heller, Daniel, Ji, Ru-Rong, Levy, Bruce D., Kumar, Krishna, Kopin, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036347/
https://ncbi.nlm.nih.gov/pubmed/24659779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522680
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