Crystal Structure and Molecular Imaging of the Na(v) Channel β3 Subunit Indicates a Trimeric Assembly

The vertebrate sodium (Na(v)) channel is composed of an ion-conducting α subunit and associated β subunits. Here, we report the crystal structure of the human β3 subunit immunoglobulin (Ig) domain, a functionally important component of Na(v) channels in neurons and cardiomyocytes. Surprisingly, we f...

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Detalhes bibliográficos
Main Authors: Namadurai, Sivakumar, Balasuriya, Dilshan, Rajappa, Rajit, Wiemhöfer, Martin, Stott, Katherine, Klingauf, Jurgen, Edwardson, J. Michael, Chirgadze, Dimitri Y., Jackson, Antony P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036194/
https://ncbi.nlm.nih.gov/pubmed/24567321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527994
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