A Charge-inverting Mutation in the “Linker” Region of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Alters Agonist Binding and Gating Kinetics Independently of Allosteric Modulators

AMPA receptors are gated through binding of glutamate to a solvent-accessible ligand-binding domain. Upon glutamate binding, these receptors undergo a series of conformational rearrangements regulating channel function. Allosteric modulators can bind within a pocket adjacent to the ligand-binding do...

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Detalhes bibliográficos
Main Authors: Harms, Jonathan E., Benveniste, Morris, Kessler, Markus, Stone, Leslie M., Arai, Amy C., Partin, Kathryn M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036187/
https://ncbi.nlm.nih.gov/pubmed/24550387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526921
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