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Conserved electron donor complex Dre2–Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis
Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)(2)-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inact...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035922/ https://ncbi.nlm.nih.gov/pubmed/24733891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405204111 |
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