Conserved electron donor complex Dre2–Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis

Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)(2)-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inact...

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Autores principales: Zhang, Yan, Li, Haoran, Zhang, Caiguo, An, Xiuxiang, Liu, Lili, Stubbe, JoAnne, Huang, Mingxia
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035922/
https://ncbi.nlm.nih.gov/pubmed/24733891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405204111
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