X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking

Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled by the pituitary h...

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Hauptverfasser: Frick, Anna, Eriksson, Urszula Kosinska, de Mattia, Fabrizio, Öberg, Fredrik, Hedfalk, Kristina, Neutze, Richard, de Grip, Willem J., Deen, Peter M. T., Törnroth-Horsefield, Susanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035913/
https://ncbi.nlm.nih.gov/pubmed/24733887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321406111
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