Global microRNA depletion suppresses tumor angiogenesis

MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signalin...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chen, Sidi, Xue, Yuan, Wu, Xuebing, Le, Cong, Bhutkar, Arjun, Bell, Eric L., Zhang, Feng, Langer, Robert, Sharp, Phillip A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035535/
https://ncbi.nlm.nih.gov/pubmed/24788094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.239681.114
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