Orbitofrontal Dopamine Depletion Upregulates Caudate Dopamine and Alters Behavior via Changes in Reinforcement Sensitivity

Schizophrenia is associated with upregulation of dopamine (DA) release in the caudate nucleus. The caudate has dense connections with the orbitofrontal cortex (OFC) via the frontostriatal loops, and both areas exhibit pathophysiological change in schizophrenia. Despite evidence that abnormalities in...

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Autors principals: Clarke, H. F., Cardinal, R. N., Rygula, R., Hong, Y. T., Fryer, T. D., Sawiak, S. J., Ferrari, V., Cockcroft, G., Aigbirhio, F. I., Robbins, T. W., Roberts, A. C.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035526/
https://ncbi.nlm.nih.gov/pubmed/24872570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0718-14.2014
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